Digoxin is a potent pro-arrhythmic drug. At therapeutic plasma level, it causes nonspecific ST segment depression that has a scooping appearance (A) or looks like a reversed ¡§?¡¨ (B).
Quinidine, procainamide, and disopyramide (
Sotalol and amiodarone (Class III agents) can increase PR, QRS, and QT intervals, leading to similar risks of torsade de pointes. They also have significant beta-blocking properties, causing bradyarrhythmias.